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I always thought drugs were tested on and dosed based on men so many side effects for women were considered strange or psychological.

Ironically I read somewhere that improving compliance actually had worse results because of increased side effects. In most cases (except antibiotics I suppose) a missed dose every once in a while can be beneficial.

Perhaps they need to broaden the testing field after the first round to check further for side effects. I understand the need for more stringent requirements because of possible effects on a developing fetus but come on, there are some difference even before you take size into account.

Irving TX
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FF One does not have to pee on a fence to discover it is electrified.

Woodville TX
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Fun fact #2: Phase I clinical trials are almost always conducted only on young men. Care to guess why?

Windermere FL
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Fun fact #1: Most men underdose on prescriptions.

Generally, prescription dosing does not take into account the size or gender of the patient. A round of azithromycin is the same for a 250 pound man as it is for a 100 pound woman.

When it comes to dosing recommendations, manufacturers make pills intended for 100 pound women. If the prescribing doctor doesn't take into account differences in the size of the patient (and often gender), this means that a small woman feels the full force of the drug (for good or bad) while a large man does not.

Many drugs are metabolized considerably faster by men, even when correcting for body weight. This is not well understood, but for Ambien, for instance, a 250 pound man will clear it about 4 times as fast as a 100 pound woman, higher than one would predict based on the body weight difference.

Windermere FL
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What did the US respond back with? " I could tell you but then I would have to kill you"?

Rutherford NJ
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Fun Fact:

The first message sent to Moscow via the Washington-Moscow Hotline was a (very common) test message, reading "THE QUICK BROWN FOX JUMPS OVER THE LAZY DOG 1234567890".

Moscow, competent in English but not familiar with the use of the sentence for typography testing, responded with "What do your people mean when they say "The quick brown fox jumps over the lazy dog"?"

Windermere FL
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Heya VA

Still around, mostly lurking all of the interesting conversations. Hope all is well?

San Antonio TX
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Two of my kids had a mild reaction to amoxicillin one time. Now they avoid prescribing it.

I think it might have just been something with that batch...

Fullerton CA
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"Was that the sound of VA's head exploding? Lol"

It would have been, had I not been wearing a copper protective wristband.

---

Hey SA! Long time no see!

Windermere FL
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It gives me a terrible sick headache. At first I just thought that they were ineffective against migraines and my symptoms were from migraine. Now I believe that my symptoms are from the Tylenol itself after I was accidentally prescribed a form of Tulonol because my doctor didn't want me to take ibuprofen or aspirin.

Irving TX
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TOPIC: Fun Facts
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